Description

Pemetrexed disodium henipentahydrate is a pharmaceutical compound that is primarily used as a chemotherapy drug in the treatment of certain types of cancer. It is the disodium salt of pemetrexed, a multitargeted antifolate agent that inhibits several enzymes involved in folate metabolism, which are necessary for the production of nucleotides. These nucleotides are vital for the synthesis of DNA and RNA, and by inhibiting their production, pemetrexed disrupts the growth and proliferation of cancer cells.

Key Applications and Benefits of Pemetrexed Disodium Henipentahydrate:

1. Cancer Treatment: Pemetrexed is commonly used in the treatment of non-small cell lung cancer (NSCLC) and malignant pleural mesothelioma, two aggressive forms of cancer. It is often used in combination with other chemotherapy drugs to improve efficacy.
2. Mechanism of Action: Pemetrexed works by inhibiting enzymes such as thymidylate synthase, dihydrofolate reductase, and glycinamide ribonucleotide formyltransferase. These enzymes are critical in the folate pathway, which cancer cells rely on for rapid growth and division. By blocking these enzymes, pemetrexed slows or stops the growth of cancer cells.
3. Combination Therapy: It is typically administered in combination with other chemotherapy drugs, such as cisplatin, to enhance its effectiveness in treating advanced stages of cancer. This combination is especially useful for treating cancers that are resistant to single-agent therapies.
4. Improved Survival Outcomes: Studies have shown that pemetrexed, particularly when combined with cisplatin, improves progression-free survival and overall survival in patients with advanced lung cancer and mesothelioma.
5. Hydration Benefits: The henipentahydrate form of pemetrexed disodium is hydrated with five water molecules, which may help improve solubility and stability, facilitating the preparation of intravenous (IV) solutions for administration.Altico Biotech is a leading API raw material supplier and pharmaceutical raw materials manufacturer, specializing in delivering high-quality ingredients for pharmaceuticals, cosmetics, and health food industries. As a trusted cosmetic ingredients supplier, they provide organic raw materials for cosmetics, including herbal extracts for cosmetics, ensuring natural and sustainable formulations. Their portfolio includes active pharmaceutical ingredients (API), nutraceutical raw materials, and bulk health food raw materials, catering to the growing demand for health and wellness products. Altico Biotech is your reliable partner for innovative and high-grade natural health food ingredients and nutraceutical raw materials supplier solutions.