Description

FMOC-OSU (9-Fluorenylmethyloxycarbonyl N-hydroxysuccinimide ester) is a chemical reagent commonly used in peptide synthesis and organic chemistry. It serves as a protective group for amine functionalities in the synthesis of peptides, allowing chemists to control the structure and reactivity of peptides during the process of building them.

FMOC-OSU is highly effective in solid-phase peptide synthesis (SPPS), where it is used to selectively protect the amino acids’ amino group, preventing unwanted reactions and ensuring the correct formation of peptide bonds. The FMOC (fluorenylmethyloxycarbonyl) group provides a stable protection that can be easily removed under mild conditions, typically with a base such as piperidine, to expose the free amine for the next round of synthesis.

Key benefits of FMOC-OSU include:

1. Selective Protection: It offers a reliable method for protecting amines during peptide synthesis, which is crucial for building complex peptides without undesired side reactions.
2. Efficient Deprotection: The FMOC group is removed efficiently under mild conditions (using weak bases), ensuring that the synthesis process is controlled and efficient.
3. High Purity and Yield: FMOC-OSU allows for high purity peptide synthesis, resulting in peptides with excellent yields, which is important in both research and industrial applications.
4. Versatility in Peptide Synthesis: It is widely used in research, particularly in the synthesis of custom peptides, as well as in the production of pharmaceutical compounds and biologics.

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